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gd1a d18  (Croda International Plc)

 
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    Structured Review

    Croda International Plc gd1a d18
    Absolute quantitation of the ganglioside profile in ten functional brain regions from relative abundance values obtained from a 72-year-old male with no sign of cognitive impairment. Each representative ganglioside included both the a- and b-series glycan structures for the major ceramide structures <t>d18:1/C16,</t> <t>C18,</t> C20, and C22 when observed in the depicted region.
    Gd1a D18, supplied by Croda International Plc, used in various techniques. Bioz Stars score: 94/100, based on 5 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/gd1a+d18/C18%3A0+GD1a/pmc12021261-139-18-29
    Average 94 stars, based on 5 article reviews
    gd1a d18 - by Bioz Stars, 2026-09
    94/100 stars

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    1) Product Images from "Region-specific quantitation of glycosphingolipids in the elderly human brain with Nanoflow MEA Chip Q/ToF mass spectrometry"

    Article Title: Region-specific quantitation of glycosphingolipids in the elderly human brain with Nanoflow MEA Chip Q/ToF mass spectrometry

    Journal: Glycobiology

    doi: 10.1093/glycob/cwaf022

    Absolute quantitation of the ganglioside profile in ten functional brain regions from relative abundance values obtained from a 72-year-old male with no sign of cognitive impairment. Each representative ganglioside included both the a- and b-series glycan structures for the major ceramide structures d18:1/C16, C18, C20, and C22 when observed in the depicted region.
    Figure Legend Snippet: Absolute quantitation of the ganglioside profile in ten functional brain regions from relative abundance values obtained from a 72-year-old male with no sign of cognitive impairment. Each representative ganglioside included both the a- and b-series glycan structures for the major ceramide structures d18:1/C16, C18, C20, and C22 when observed in the depicted region.

    Techniques Used: Quantitation Assay, Functional Assay, Glycoproteomics

    Absolute quantitation of the major ganglioside species observed in the temporal cortex for comparison of age matched controls NCI-72 & HS-95 to autopsy confirmed Alzheimer disease subjects AD-74 & AD-93. Each representative ganglioside included both a- and b-series glycan structures for the major ceramide structures d18:1/C16, C18, C20, and C22.
    Figure Legend Snippet: Absolute quantitation of the major ganglioside species observed in the temporal cortex for comparison of age matched controls NCI-72 & HS-95 to autopsy confirmed Alzheimer disease subjects AD-74 & AD-93. Each representative ganglioside included both a- and b-series glycan structures for the major ceramide structures d18:1/C16, C18, C20, and C22.

    Techniques Used: Quantitation Assay, Comparison, Glycoproteomics

    Example ganglioside elution profile and identifying MS 2 product ions produced by nanoHPLC-MEAchip-Q/ToF analysis. Depicted isomeric structures include glycan a- & b-series isomers (GD1a & GD1b) with ceramide isomers (d18:1/CN & d20:1/CN).
    Figure Legend Snippet: Example ganglioside elution profile and identifying MS 2 product ions produced by nanoHPLC-MEAchip-Q/ToF analysis. Depicted isomeric structures include glycan a- & b-series isomers (GD1a & GD1b) with ceramide isomers (d18:1/CN & d20:1/CN).

    Techniques Used: Produced, Glycoproteomics

    Related Articles

    Quantitation Assay:

    Article Title: Region-specific quantitation of glycosphingolipids in the elderly human brain with Nanoflow MEA Chip Q/ToF mass spectrometry
    Article Snippet: Sphingomyelin-d18:1/C18 (Cat# 860586), Sphingomyelin-d18:1/C24:1 (Cat# 860593), Glucose-d18:1/C24:1 (Cat# 860549), SM4-d18:1/C24:1 (Cat# 860571), GM1a-d18:1/C18 (Cat# 860588), GM3-d18:1/C18 (Cat# 860074), GD1a-d18:1/C18 (Cat# 860091), and GT1b-d18:1/C18 (Cat# 860089) standards were purchased from Avanti Polar Lipids (Alabaster, AL).. Lymphoblast CESS cells (Cat# TIB-190) were obtained from the American Type Cell Culture (Manassas, VA).Lymphoblast CESS cells (Cat# TIB-190) were obtained from the American Type Cell Culture (Manassas, VA).

    Article Title: Profiling Intact Glycosphingolipids with Automated Structural Annotation and Quantitation from Human Samples with Nanoflow Liquid Chromatography Mass Spectrometry.
    Article Snippet: ■ METHODS Materials and Chemicals.■ METHODS Materials and Chemicals.. Sphingomyelin-d18:1/C18 (SM-d18:1/C18, Cat# 860586), Sphingomyelin-d18:1/C24:1 (SM-d18:1/C24:1, Cat# 860593), Glucose-d18:1/C24:1 (Glcd18:1/C24:1, Cat# 860549), Sulfo-galactose-d18:1/C24:1 (SHex-d18:1/C24:1, Cat# 860571), GM1a-d18:1/C20 (Cat# 860588), GM3-d18:1/C18 (Cat# 860074), GD1a-d18:1/C18 (Cat# 860091), and GT1b-d18:1/C18 (Cat# 860089) standards were purchased from Avanti Polar Lipids (Alabaster, AL).. Lymphoblast CESS cells (Cat# TIB-190) were obtained from the American Type Cell Culture (Manassas, VA). α2−3,6,8 Neuraminidase (Cat# P0720) was purchased from New England Biolabs (Ipswich, MA).Lymphoblast CESS cells (Cat# TIB-190) were obtained from the American Type Cell Culture (Manassas, VA). α2−3,6,8 Neuraminidase (Cat# P0720) was purchased from New England Biolabs (Ipswich, MA).

    Functional Assay:

    Article Title: Region-specific quantitation of glycosphingolipids in the elderly human brain with Nanoflow MEA Chip Q/ToF mass spectrometry
    Article Snippet: Sphingomyelin-d18:1/C18 (Cat# 860586), Sphingomyelin-d18:1/C24:1 (Cat# 860593), Glucose-d18:1/C24:1 (Cat# 860549), SM4-d18:1/C24:1 (Cat# 860571), GM1a-d18:1/C18 (Cat# 860588), GM3-d18:1/C18 (Cat# 860074), GD1a-d18:1/C18 (Cat# 860091), and GT1b-d18:1/C18 (Cat# 860089) standards were purchased from Avanti Polar Lipids (Alabaster, AL).. Lymphoblast CESS cells (Cat# TIB-190) were obtained from the American Type Cell Culture (Manassas, VA).Lymphoblast CESS cells (Cat# TIB-190) were obtained from the American Type Cell Culture (Manassas, VA).

    Article Title: Profiling Intact Glycosphingolipids with Automated Structural Annotation and Quantitation from Human Samples with Nanoflow Liquid Chromatography Mass Spectrometry.
    Article Snippet: ■ METHODS Materials and Chemicals.■ METHODS Materials and Chemicals.. Sphingomyelin-d18:1/C18 (SM-d18:1/C18, Cat# 860586), Sphingomyelin-d18:1/C24:1 (SM-d18:1/C24:1, Cat# 860593), Glucose-d18:1/C24:1 (Glcd18:1/C24:1, Cat# 860549), Sulfo-galactose-d18:1/C24:1 (SHex-d18:1/C24:1, Cat# 860571), GM1a-d18:1/C20 (Cat# 860588), GM3-d18:1/C18 (Cat# 860074), GD1a-d18:1/C18 (Cat# 860091), and GT1b-d18:1/C18 (Cat# 860089) standards were purchased from Avanti Polar Lipids (Alabaster, AL).. Lymphoblast CESS cells (Cat# TIB-190) were obtained from the American Type Cell Culture (Manassas, VA). α2−3,6,8 Neuraminidase (Cat# P0720) was purchased from New England Biolabs (Ipswich, MA).Lymphoblast CESS cells (Cat# TIB-190) were obtained from the American Type Cell Culture (Manassas, VA). α2−3,6,8 Neuraminidase (Cat# P0720) was purchased from New England Biolabs (Ipswich, MA).

    Glycoproteomics:

    Article Title: Region-specific quantitation of glycosphingolipids in the elderly human brain with Nanoflow MEA Chip Q/ToF mass spectrometry
    Article Snippet: Sphingomyelin-d18:1/C18 (Cat# 860586), Sphingomyelin-d18:1/C24:1 (Cat# 860593), Glucose-d18:1/C24:1 (Cat# 860549), SM4-d18:1/C24:1 (Cat# 860571), GM1a-d18:1/C18 (Cat# 860588), GM3-d18:1/C18 (Cat# 860074), GD1a-d18:1/C18 (Cat# 860091), and GT1b-d18:1/C18 (Cat# 860089) standards were purchased from Avanti Polar Lipids (Alabaster, AL).. Lymphoblast CESS cells (Cat# TIB-190) were obtained from the American Type Cell Culture (Manassas, VA).Lymphoblast CESS cells (Cat# TIB-190) were obtained from the American Type Cell Culture (Manassas, VA).

    Article Title: Profiling Intact Glycosphingolipids with Automated Structural Annotation and Quantitation from Human Samples with Nanoflow Liquid Chromatography Mass Spectrometry.
    Article Snippet: ■ METHODS Materials and Chemicals.■ METHODS Materials and Chemicals.. Sphingomyelin-d18:1/C18 (SM-d18:1/C18, Cat# 860586), Sphingomyelin-d18:1/C24:1 (SM-d18:1/C24:1, Cat# 860593), Glucose-d18:1/C24:1 (Glcd18:1/C24:1, Cat# 860549), Sulfo-galactose-d18:1/C24:1 (SHex-d18:1/C24:1, Cat# 860571), GM1a-d18:1/C20 (Cat# 860588), GM3-d18:1/C18 (Cat# 860074), GD1a-d18:1/C18 (Cat# 860091), and GT1b-d18:1/C18 (Cat# 860089) standards were purchased from Avanti Polar Lipids (Alabaster, AL).. Lymphoblast CESS cells (Cat# TIB-190) were obtained from the American Type Cell Culture (Manassas, VA). α2−3,6,8 Neuraminidase (Cat# P0720) was purchased from New England Biolabs (Ipswich, MA).Lymphoblast CESS cells (Cat# TIB-190) were obtained from the American Type Cell Culture (Manassas, VA). α2−3,6,8 Neuraminidase (Cat# P0720) was purchased from New England Biolabs (Ipswich, MA).

    Comparison:

    Article Title: Region-specific quantitation of glycosphingolipids in the elderly human brain with Nanoflow MEA Chip Q/ToF mass spectrometry
    Article Snippet: Sphingomyelin-d18:1/C18 (Cat# 860586), Sphingomyelin-d18:1/C24:1 (Cat# 860593), Glucose-d18:1/C24:1 (Cat# 860549), SM4-d18:1/C24:1 (Cat# 860571), GM1a-d18:1/C18 (Cat# 860588), GM3-d18:1/C18 (Cat# 860074), GD1a-d18:1/C18 (Cat# 860091), and GT1b-d18:1/C18 (Cat# 860089) standards were purchased from Avanti Polar Lipids (Alabaster, AL).. Lymphoblast CESS cells (Cat# TIB-190) were obtained from the American Type Cell Culture (Manassas, VA).Lymphoblast CESS cells (Cat# TIB-190) were obtained from the American Type Cell Culture (Manassas, VA).

    Article Title: Profiling Intact Glycosphingolipids with Automated Structural Annotation and Quantitation from Human Samples with Nanoflow Liquid Chromatography Mass Spectrometry.
    Article Snippet: ■ METHODS Materials and Chemicals.■ METHODS Materials and Chemicals.. Sphingomyelin-d18:1/C18 (SM-d18:1/C18, Cat# 860586), Sphingomyelin-d18:1/C24:1 (SM-d18:1/C24:1, Cat# 860593), Glucose-d18:1/C24:1 (Glcd18:1/C24:1, Cat# 860549), Sulfo-galactose-d18:1/C24:1 (SHex-d18:1/C24:1, Cat# 860571), GM1a-d18:1/C20 (Cat# 860588), GM3-d18:1/C18 (Cat# 860074), GD1a-d18:1/C18 (Cat# 860091), and GT1b-d18:1/C18 (Cat# 860089) standards were purchased from Avanti Polar Lipids (Alabaster, AL).. Lymphoblast CESS cells (Cat# TIB-190) were obtained from the American Type Cell Culture (Manassas, VA). α2−3,6,8 Neuraminidase (Cat# P0720) was purchased from New England Biolabs (Ipswich, MA).Lymphoblast CESS cells (Cat# TIB-190) were obtained from the American Type Cell Culture (Manassas, VA). α2−3,6,8 Neuraminidase (Cat# P0720) was purchased from New England Biolabs (Ipswich, MA).

    Produced:

    Article Title: Region-specific quantitation of glycosphingolipids in the elderly human brain with Nanoflow MEA Chip Q/ToF mass spectrometry
    Article Snippet: Sphingomyelin-d18:1/C18 (Cat# 860586), Sphingomyelin-d18:1/C24:1 (Cat# 860593), Glucose-d18:1/C24:1 (Cat# 860549), SM4-d18:1/C24:1 (Cat# 860571), GM1a-d18:1/C18 (Cat# 860588), GM3-d18:1/C18 (Cat# 860074), GD1a-d18:1/C18 (Cat# 860091), and GT1b-d18:1/C18 (Cat# 860089) standards were purchased from Avanti Polar Lipids (Alabaster, AL).. Lymphoblast CESS cells (Cat# TIB-190) were obtained from the American Type Cell Culture (Manassas, VA).Lymphoblast CESS cells (Cat# TIB-190) were obtained from the American Type Cell Culture (Manassas, VA).

    Article Title: Profiling Intact Glycosphingolipids with Automated Structural Annotation and Quantitation from Human Samples with Nanoflow Liquid Chromatography Mass Spectrometry.
    Article Snippet: ■ METHODS Materials and Chemicals.■ METHODS Materials and Chemicals.. Sphingomyelin-d18:1/C18 (SM-d18:1/C18, Cat# 860586), Sphingomyelin-d18:1/C24:1 (SM-d18:1/C24:1, Cat# 860593), Glucose-d18:1/C24:1 (Glcd18:1/C24:1, Cat# 860549), Sulfo-galactose-d18:1/C24:1 (SHex-d18:1/C24:1, Cat# 860571), GM1a-d18:1/C20 (Cat# 860588), GM3-d18:1/C18 (Cat# 860074), GD1a-d18:1/C18 (Cat# 860091), and GT1b-d18:1/C18 (Cat# 860089) standards were purchased from Avanti Polar Lipids (Alabaster, AL).. Lymphoblast CESS cells (Cat# TIB-190) were obtained from the American Type Cell Culture (Manassas, VA). α2−3,6,8 Neuraminidase (Cat# P0720) was purchased from New England Biolabs (Ipswich, MA).Lymphoblast CESS cells (Cat# TIB-190) were obtained from the American Type Cell Culture (Manassas, VA). α2−3,6,8 Neuraminidase (Cat# P0720) was purchased from New England Biolabs (Ipswich, MA).

    Tandem Mass Spectroscopy:

    Article Title: Region-specific quantitation of glycosphingolipids in the elderly human brain with Nanoflow MEA Chip Q/ToF mass spectrometry
    Article Snippet: Sphingomyelin-d18:1/C18 (Cat# 860586), Sphingomyelin-d18:1/C24:1 (Cat# 860593), Glucose-d18:1/C24:1 (Cat# 860549), SM4-d18:1/C24:1 (Cat# 860571), GM1a-d18:1/C18 (Cat# 860588), GM3-d18:1/C18 (Cat# 860074), GD1a-d18:1/C18 (Cat# 860091), and GT1b-d18:1/C18 (Cat# 860089) standards were purchased from Avanti Polar Lipids (Alabaster, AL).. Lymphoblast CESS cells (Cat# TIB-190) were obtained from the American Type Cell Culture (Manassas, VA).Lymphoblast CESS cells (Cat# TIB-190) were obtained from the American Type Cell Culture (Manassas, VA).

    Article Title: Profiling Intact Glycosphingolipids with Automated Structural Annotation and Quantitation from Human Samples with Nanoflow Liquid Chromatography Mass Spectrometry.
    Article Snippet: ■ METHODS Materials and Chemicals.■ METHODS Materials and Chemicals.. Sphingomyelin-d18:1/C18 (SM-d18:1/C18, Cat# 860586), Sphingomyelin-d18:1/C24:1 (SM-d18:1/C24:1, Cat# 860593), Glucose-d18:1/C24:1 (Glcd18:1/C24:1, Cat# 860549), Sulfo-galactose-d18:1/C24:1 (SHex-d18:1/C24:1, Cat# 860571), GM1a-d18:1/C20 (Cat# 860588), GM3-d18:1/C18 (Cat# 860074), GD1a-d18:1/C18 (Cat# 860091), and GT1b-d18:1/C18 (Cat# 860089) standards were purchased from Avanti Polar Lipids (Alabaster, AL).. Lymphoblast CESS cells (Cat# TIB-190) were obtained from the American Type Cell Culture (Manassas, VA). α2−3,6,8 Neuraminidase (Cat# P0720) was purchased from New England Biolabs (Ipswich, MA).Lymphoblast CESS cells (Cat# TIB-190) were obtained from the American Type Cell Culture (Manassas, VA). α2−3,6,8 Neuraminidase (Cat# P0720) was purchased from New England Biolabs (Ipswich, MA).



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    Absolute quantitation of the ganglioside profile in ten functional brain regions from relative abundance values obtained from a 72-year-old male with no sign of cognitive impairment. Each representative ganglioside included both the a- and b-series glycan structures for the major ceramide structures d18:1/C16, C18, C20, and C22 when observed in the depicted region.

    Journal: Glycobiology

    Article Title: Region-specific quantitation of glycosphingolipids in the elderly human brain with Nanoflow MEA Chip Q/ToF mass spectrometry

    doi: 10.1093/glycob/cwaf022

    Figure Lengend Snippet: Absolute quantitation of the ganglioside profile in ten functional brain regions from relative abundance values obtained from a 72-year-old male with no sign of cognitive impairment. Each representative ganglioside included both the a- and b-series glycan structures for the major ceramide structures d18:1/C16, C18, C20, and C22 when observed in the depicted region.

    Article Snippet: Sphingomyelin-d18:1/C18 (Cat# 860586), Sphingomyelin-d18:1/C24:1 (Cat# 860593), Glucose-d18:1/C24:1 (Cat# 860549), SM4-d18:1/C24:1 (Cat# 860571), GM1a-d18:1/C18 (Cat# 860588), GM3-d18:1/C18 (Cat# 860074), GD1a-d18:1/C18 (Cat# 860091), and GT1b-d18:1/C18 (Cat# 860089) standards were purchased from Avanti Polar Lipids (Alabaster, AL).

    Techniques: Quantitation Assay, Functional Assay, Glycoproteomics

    Absolute quantitation of the major ganglioside species observed in the temporal cortex for comparison of age matched controls NCI-72 & HS-95 to autopsy confirmed Alzheimer disease subjects AD-74 & AD-93. Each representative ganglioside included both a- and b-series glycan structures for the major ceramide structures d18:1/C16, C18, C20, and C22.

    Journal: Glycobiology

    Article Title: Region-specific quantitation of glycosphingolipids in the elderly human brain with Nanoflow MEA Chip Q/ToF mass spectrometry

    doi: 10.1093/glycob/cwaf022

    Figure Lengend Snippet: Absolute quantitation of the major ganglioside species observed in the temporal cortex for comparison of age matched controls NCI-72 & HS-95 to autopsy confirmed Alzheimer disease subjects AD-74 & AD-93. Each representative ganglioside included both a- and b-series glycan structures for the major ceramide structures d18:1/C16, C18, C20, and C22.

    Article Snippet: Sphingomyelin-d18:1/C18 (Cat# 860586), Sphingomyelin-d18:1/C24:1 (Cat# 860593), Glucose-d18:1/C24:1 (Cat# 860549), SM4-d18:1/C24:1 (Cat# 860571), GM1a-d18:1/C18 (Cat# 860588), GM3-d18:1/C18 (Cat# 860074), GD1a-d18:1/C18 (Cat# 860091), and GT1b-d18:1/C18 (Cat# 860089) standards were purchased from Avanti Polar Lipids (Alabaster, AL).

    Techniques: Quantitation Assay, Comparison, Glycoproteomics

    Example ganglioside elution profile and identifying MS 2 product ions produced by nanoHPLC-MEAchip-Q/ToF analysis. Depicted isomeric structures include glycan a- & b-series isomers (GD1a & GD1b) with ceramide isomers (d18:1/CN & d20:1/CN).

    Journal: Glycobiology

    Article Title: Region-specific quantitation of glycosphingolipids in the elderly human brain with Nanoflow MEA Chip Q/ToF mass spectrometry

    doi: 10.1093/glycob/cwaf022

    Figure Lengend Snippet: Example ganglioside elution profile and identifying MS 2 product ions produced by nanoHPLC-MEAchip-Q/ToF analysis. Depicted isomeric structures include glycan a- & b-series isomers (GD1a & GD1b) with ceramide isomers (d18:1/CN & d20:1/CN).

    Article Snippet: Sphingomyelin-d18:1/C18 (Cat# 860586), Sphingomyelin-d18:1/C24:1 (Cat# 860593), Glucose-d18:1/C24:1 (Cat# 860549), SM4-d18:1/C24:1 (Cat# 860571), GM1a-d18:1/C18 (Cat# 860588), GM3-d18:1/C18 (Cat# 860074), GD1a-d18:1/C18 (Cat# 860091), and GT1b-d18:1/C18 (Cat# 860089) standards were purchased from Avanti Polar Lipids (Alabaster, AL).

    Techniques: Produced, Glycoproteomics

    (A) Elution profile of representative LCBs. The MS/MS spectra of GM1-LCB/C18 with (B) d18:2, (C) t18:0, and (D) d18:0.

    Journal: Analytical Chemistry

    Article Title: Profiling Intact Glycosphingolipids with Automated Structural Annotation and Quantitation from Human Samples with Nanoflow Liquid Chromatography Mass Spectrometry

    doi: 10.1021/acs.analchem.4c00077

    Figure Lengend Snippet: (A) Elution profile of representative LCBs. The MS/MS spectra of GM1-LCB/C18 with (B) d18:2, (C) t18:0, and (D) d18:0.

    Article Snippet: Sphingomyelin-d18:1/C18 (SM-d18:1/C18, Cat# 860586), Sphingomyelin-d18:1/C24:1 (SM-d18:1/C24:1, Cat# 860593), Glucose-d18:1/C24:1 (Glc-d18:1/C24:1, Cat# 860549), Sulfo-galactose-d18:1/C24:1 (SHex-d18:1/C24:1, Cat# 860571), GM1 a -d18:1/C20 (Cat# 860588), GM3-d18:1/C18 (Cat# 860074), GD1 a -d18:1/C18 (Cat# 860091), and GT1 b -d18:1/C18 (Cat# 860089) standards were purchased from Avanti Polar Lipids (Alabaster, AL).

    Techniques: Tandem Mass Spectroscopy